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The Future Medicines Institute (FMI) requires a high throughput live-cell imaging system to enable FMI scientists and collaborators to monitor live cell imaging in real time under optimal conditions of cell growth in a properly maintained carbon dioxide and humidity environment to enable the efficient capture of cellular changes as they happen in the incubator. The objective of procuring a live cell imaging system is to enhance FMI’s capacity to monitor cells in real time, in an optimally controlled environment, to support and strengthen its drug discovery capabilities. The proposed system must: • Be capable of multiplate/vessel imaging, up to a capacity of 6 plates/vessels and including capacity to image 6 384 well plates, to meet the volume of analysis that the centre is undertaking and support high throughput drug screening projects. • Enable high resolution fluorescence and bright field images to be captured and recorded in real time over hours, days, or weeks. • Offer flexibility to enable users to observe and quantify complex biological changes over time in cells and 3d structures such as spheroids and organoid models. • Include a fully integrated image acquisition system
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